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1996-02-27
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Document 0614
DOCN M9630614
TI Long-chain polyunsaturated fatty acids in children with severe
protein-energy malnutrition with and without human immunodeficiency
virus-1 infection.
DT 9603
AU Decsi T; Zaknun D; Zaknun J; Sperl W; Koletzko B; Kinderpoliklinik,
Ludwig-Maximilians-University, Munich, Germany.
SO Am J Clin Nutr. 1995 Dec;62(6):1283-8. Unique Identifier : AIDSLINE
MED/96094678
AB Fatty acids in plasma phospholipids were studied in 35 severely
malnourished young children with a median age of 29 mo (range: 9-43 mo),
who were either seronegative for human immunodeficiency virus-1 (HIV) (n
= 16) or suffered from asymptomatic (stage P-1; n = 12) or symptomatic
(stage P-2; n = 7) HIV disease. The malnourished children had
significantly lower percentages (% by wt) of phospholipid arachidonic
(20:4n-6, AA) and docosahexaenoic (22:6n-3, DHA) acids than 25
age-matched healthy control subjects (AA: 7.05% and 8.70% by wt; DHA:
0.92 and 2.61% by wt, P < 0.001). Body weights of malnourished children
did not correlate with linoleic (18:2n-6) and alpha-linolenic (18:3n-3)
acid values but were significantly and positively correlated with AA and
DHA values (r = 0.40, P = 0.02 and r = 0.63, P < 0.0001, respectively).
Plasma concentrations (mg/L) of total phospholipid fatty acids did not
differ among seronegative, stage P-1, or stage P-2 patients. Percentage
contributions of AA and eicosapentaenoic acid (20:5n-3, EPA) did not
differ among those seronegative or in stages P-1 and P-2. In contrast,
values of dihomo-gamma-linolenic acid (20:3n-6) were significantly (P <
0.05) lower in stage P-2 (2.38 mg/L) than in either seronegative (3.47
mg/L) or stage P-1 (3.66 mg/L) patients. We conclude that the severely
malnourished children developed a depletion of both AA and DHA
proportional to the degree of malnutrition.(ABSTRACT TRUNCATED AT 250
WORDS)
DE Arachidonic Acids/BLOOD Body Weight/PHYSIOLOGY Child, Preschool
Comparative Study Docosahexaenoic Acids/BLOOD Fatty Acids,
Unsaturated/*BLOOD/METABOLISM Human HIV
Infections/*BLOOD/COMPLICATIONS/PHYSIOPATHOLOGY *HIV-1 Infant
Linoleic Acids/BLOOD Phospholipids/BLOOD Protein-Energy
Malnutrition/*BLOOD/COMPLICATIONS/PHYSIOPATHOLOGY Support, Non-U.S.
Gov't 5,8,11,14,17-Eicosapentaenoic Acid/BLOOD JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).